Our research projects Filtre Biologie cellulaire Ciblage thérapeutique Développement Différenciation cellulaire Epigénétique Cellules souches Génétique Génomique et régulation du génome Hématologie Immunité adaptative Immunité innée Immunothérapie Métabolisme Microbiote Reproduction et périnatalité Signalisation cellulaire Vieillissement Cancer COVID-19 Diabète et autres maladies métaboliques Infections bactériennes Infections parasitaires Infections virales Maladies auto-immunes Maladies inflammatoires chroniques Maladies rares SIDA/VIH Disease/Research area Immunologie Cancer Métabolisme et endocrinologie Microbiologie Plasticité cellulaire et reproduction Plateformes technologiques Scientific axis Key words Filtrer RNA metabolism and HIV latency The eradication of HIV faces a major obstacle, which is viral persistence in reservoir cells despite antiretroviral treatment. HIV latency… Roy MATKOVIC Microbiology Cellular plasticity and reproduction Local role of hepcidin in the setting of inflammation, infection and cancer Carole PEYSSONNAUX Sophie VAULONT Metabolism and endocrinology Interferences with cellular bioenergetics, causes and consequences After oxidation of substrates by metabolism (see introduction) the metabolic energy could be transformed in different forms: 1) hydrogen ions… Frédéric BOUILLAUD Metabolism and endocrinology Study of the physiological functions of serotonin Research on serotonin (5-hydroxytryptamine or 5-HT) has primarily focused on its role as a neurotransmitter in the central nervous system… Metabolism and endocrinology Restriction factors and lentiviral antagonism Florence Margottin-Goguet’s group has a long-standing interest in the study of host immune defense proteins, the so-called restriction factors and… Florence MARGOTTIN-GOGUET Microbiology Cellular plasticity and reproduction Identify new GPCR genes associated with obesity and Type 2 diabetes Julie DAM Ralf JOCKERS Metabolism and endocrinology Quantitative Evolutionary Microbiology Research topic With the rise of antibiotic resistance and the emergence of new forms of virulence, it has become clear… Olivier TENAILLON Microbiology Mechanical perturbations of the immune synapse Paolo PIEROBON Immunology Polarity and dynamics of lymphocytes Paolo PIEROBON Immunology Role of ChREBP in inter-organ crosstalk and energy homeostasis Modelization and key features of microenvironment in MDS and VEXAS syndrome Olivier KOSMIDER Cancer Deciphering tumor-specific T cells in Acute Myeloid Leukemia Yannick SIMONI Cancer 2 3 4 5 6 7 8 9 10