Our research projects Filtre Biologie cellulaire Ciblage thérapeutique Développement Différenciation cellulaire Epigénétique Cellules souches Génétique Génomique et régulation du génome Hématologie Immunité adaptative Immunité innée Immunothérapie Métabolisme Microbiote Reproduction et périnatalité Signalisation cellulaire Vieillissement Cancer COVID-19 Diabète et autres maladies métaboliques Infections bactériennes Infections parasitaires Infections virales Maladies auto-immunes Maladies inflammatoires chroniques Maladies rares SIDA/VIH Maladies de la reproduction et de la grossesse Disease/Research area Immunologie Cancer Métabolisme et endocrinologie Microbiologie Plasticité cellulaire et reproduction Plateformes technologiques Scientific axis Key words Filtrer Role of prophages in the spread of antiviral resistance in Pseudomonas aeruginosa Almost all bacteria contain mobile genetic elements (MGE), which often carry adaptive genes such as antimicrobial resistance (AMR) and virulence… Anne CHEVALLEREAU Microbiology Rheumatoid arthritis: synovial inflammation and angiogenesis Jérôme AVOUAC Yannick ALLANORE Immunology Systemic sclerosis : pathogenesis and target therapies Yannick ALLANORE Frédéric BATTEUX Molecular and functional characterization of ADP-heptose sensing mechanism Our lab recently identified ADP-heptose, a soluble intermediate of the lipopolysaccharide (LPS) biosynthetic pathway, as a bacterial PAMP. We showed… Cécile ARRIEUMERLOU Leukemia: Genome conformation and regulatory elements Julie CHAUMEIL Cellular plasticity and reproduction Cancer V(D)J recombination: Organization, Conformation and Integrity of the Genome Julie CHAUMEIL Delphine NDIAYE-LOBRY Cellular plasticity and reproduction Cancer Immune response: X-linked determinants of sex bias The nature and the strength of the immune response differ between women and men. While women show more vigorous immune… Katia ANCELIN Julie CHAUMEIL Cellular plasticity and reproduction Dynamic of immune responses in regressing tumors and metastases We have developed several murine models in which, by mimicking local infection with type I IFNs to stimulate the immune… Nadège BERCOVICI Improving the migration and function of CAR T cells in solid tumors Adoptive transfer of T-cells expressing chimeric antigen receptors (CAR) has shown a remarkable clinical efficacy against advanced B-cell malignancies but… Emmanuel DONNADIEU The slice assay: a new preclinical model to monitor T cell activity in human tissues Emmanuel DONNADIEU How does the innate response determine the strength of memory? Molly INGERSOLL How do sex differences in immunity influence disease outcome? Molly INGERSOLL 1 2 3 4 5 6 7 8 9
