Endometriosis is a chronic hormone-dependent fibro-inflammatory gynecological disease. It affects nearly 10% of women of childbearing age and clinically results in intense pelvic pain and infertility. The disease is related to the presence of ectopic endometrium that forms cystic lesions on the ovaries and in the peritoneal cavity. The pathophysiology of this disease is poorly understood and our group has helped to elucidate certain mechanisms such as the role of oxidative stress, the activation of MAP Kinase and the mTOR / Akt pathway. Our group is particularly interested in the different adaptive or innate immune components of the chronic inflammatory response that characterizes the disease.
The gut microbiota which affects various physiological and pathological processes, such as those involving the nervous and endocrine systems and immunity, plays an important role in endocrine and inflammatory diseases. The microbial signature linked to different disorders such as endometriosis, bacterial vaginosis and gynecological cancers is described. A new study on the impact of microbiome quality under the influence of antibiotics, probiotics or diet on the development of endometriosis is underway.
Recently, we have also undertaken the study of the consequences of endometriosis during assisted reproduction and pregnancy: from fertilization / early embryonic development (non-interventional clinical study EndOvo NCT03241329) to pregnancy outcomes (prospective clinical study EndObst NCT02498691), and using a mouse model of endometriosis associated with gestation (allowing to study the tissues of interest at all stages of gestation, PlacentAtlas project). Thus, our team conducts fundamental as well as clinical research and is associated with the departments of gynecology, assisted reproductive technology, and immunology from Cochin Hospital.