A common feature of metabolic disorders, such as obesity and insulin resistance, is their association with chronic inflammatory processes, as well as a general increased risk of infections. In this context, intestinal hyperpermeability has emerged as one of the mechanistic bases contributing to this metaflammation. Among the elements triggering or supporting this loss of epithelial integrity during the "diabesity" cascade, intestinal dysbiosis, food composition and hyperglycemia have been proposed as prime candidates.