Our lab is interested in exploring the mechanisms regulating cell-cell interaction in the tissue microenvironment during leukemogenesis. The bone marrow niche is a highly vascularised multicellular unit interconnected with the haematopoietic system in health and disease. How these cells participate into the development and progression of acute leukemias is a fundamental missing piece of the puzzle. By combining cutting edge strategies such as multimodal imaging and tissue bioengineering, we aim at deciphering the role of specific mediators of these interactions in the context of acute leukemias.