The BM niche is constantly challenged by external insults, which affect the way it functions and feedbacks in turn to re-establish the homoeostatic balance. Leukemia, amongst the others, can be a long-lasting insult progressively expanding in the tissue and altering its function (Passaro et al., Immunol Rev 2016, Batsivari et al., Nat Cel Bio 2020). However, the type of interaction leukemic cells establish with environmental components is quite peculiar and specific to the nature of the cells. We aim to explore the differential alteration of the BM niche during acute myeloid and lymphoid leukemias to improve the knowledge of the differences between these diseases and identify specific novel targets.