Vascular remodelling is a complex multi-steps process, resulting from a balance between growth and regression. The bone marrow (BM) vascular system is intrinsically connected with the surrounding tissue matrix, the bone, and these two structures develop together in an intricate network of mutual signals (Abarrategi et al., J Exp Med. 2018 ; Bessy et al., Front. Cell Dev. Biol. 2021). We will combine several manufacturing approaches to bioengineer a model of the huma=n BM niche in a microfluidics chip. This alternative and flexible tool will allow to manipulate individual cell types in a highly controllable manner and analyse the response of the vasculature to specific leukemia-driven stimuli.