The "Epigenetics and nuclear functions in human diseases" team explores and analyses the role of chromatin and cell nucleus organization on key nuclear processes such as DNA replication, DNA recombination and gene expression. The aim is to understand the biological relevance of these mechanisms during development and cellular differentiation, as well as in the context of human pathologies.
Epigenetic mechanisms play a central role in the regulation of nuclear functions throughout embryonic development and adult life. Alterations in these epigenomic features are frequently associated with the onset and progression of complex diseases, such as cancer, autoimmune diseases and many rare diseases. Our main objective is to characterize the epigenetic mechanisms regulating the coordination of key nuclear processes, and to understand how their deregulation can alter human health.
The team uses a wide range of complementary techniques, from molecular and cell biology to large-scale bioinformatics analyses, using cell and mouse models as well as patient samples. It is affiliated with the "Cellular Plasticity and Reproduction" and "Cancer" scientific axes of the Institut Cochin, as well as with the research axes of the "OSCAR" rare bone, calcium and cartilage disease health network and the "React4Kids" network, with which members of the team are associated.

Main research axes:
- Characterization of new genetic and epigenetic mechanisms regulating major nuclear functions in mammals
- Study of the functions of chromatin conformation and nuclear organization in cancer initiation and progression
- Study of the functions of chromatin conformation and genome organization and regulation in rare growth disorders and autoimmune diseases.

Our research aims to provide a better understanding of the biological and molecular processes underlying human pathologies to pave the way for innovative diagnostic and therapeutic strategies.