We are focusing on the immune mechanisms that regulate this autoimmune T-cell repertoire that we all harbor and that may be lost in T1D. We are currently exploring:

  1. Pathways involved in the preferential priming of islet-reactive T cells in T1D patients.
  2. Increased resistance of effector T cells to TGF-β-mediated regulation.
  3. Defective production/signaling of pro-resolving lipid mediators.


Sylvaine You

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Roberto Mallone

Contact by email