We are focusing on the immune mechanisms that regulate this autoimmune T-cell repertoire that we all harbor and that may be lost in T1D. We are currently exploring:

1. Pathways involved in the preferential priming of islet-reactive T cells in T1D patients.
2. Increased resistance of effector T cells to TGF-β-mediated regulation.
3. Defective production/signaling of pro-resolving lipid mediators.