Epigenetics, DNA Replication and Cancer

The main objective of our team is to obtain a better understanding of the mechanisms that regulate DNA replication and the maintenance of its integrity in mammalian cells. Genome replication is carried out by a macro-molecular complex called the "replisome" that assembles at thousands of replication origins, where replication is initiated. Our team is developing original genomic, molecular biology and cell biology approaches to gain a better understanding of the actors and regulators essential to the formation and function of this complex. We are also studying the effects that a disruption of the replication process may have in the emergence of certain pathologies, such as cancer or other human diseases.

4 members

4 projects

3 grants

3 networks of excellence

23 publications


Benoit Miotto

Faculté de Médecine, 4ème Etage, 24 Rue du Faubourg Saint-Jacques, 75014 PARIS

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