Vascular remodeling and autoimmunity


Our goal is to identify target antigens and study the potential pathogenic role of autoantibodies directed against endothelial cells (Figure 1) or vascular smooth muscle cells in vascular diseases including vasculitis involving large vessels such as the Horton disease (Figure 2), arterial pulmonary hypertension and systemic sclerosis.

Legend: Anti-centromere antibodies are detected by indirect fluorescence on HEp-2 cells (upper left panel). Kidney biopsy in a patient with renal crisis depicting vascular remodeling (lower left panel). Novel targets of autoantibodies were identified using a 2-dimensional immunoblotting technique combined with mass spectrometry (right panel).

Schéma 1 projet Remodelage vasculaire et autoimmunité équipe Witko
Schéma projet Remodelage vasculaire et autoimmunité équipe Witko Remodelage vasculaire pulmonaire au cours de la sclérodermie systémique associée à une hypertension artérielle pulmonaire (ScS-HTAP)

This cartoon shows the mediators, celles and inflammatory mechanisms involved in vascular remodelling in systemic sclerosis. Vascular remodeling affects the intima, the media and the adventice of the vessels.