On Tuesday, 13 October 2026, more than 70 people attended a new Clinical and Biological Research Meeting organised by Institut Cochin and Hôpital Cochin, focusing on “GLP-1 analogues: a therapeutic revolution with societal implications”. The event brought together researchers and clinicians to review scientific and medical advances and discuss the challenges associated with these treatments.
Originally developed to treat type 2 diabetes and more recently used in the management of obesity, GLP-1 analogues are attracting growing interest because of their beneficial effects on blood glucose regulation and weight loss. Their effectiveness opens up major therapeutic opportunities while also raising medical, scientific, economic and societal questions.
Presentations explored the mechanisms of action of GLP-1 and the function of its receptor, the peripheral and central effects of GLP-1 analogues, and the clinical evidence available for treating type 2 diabetes and obesity. Their potential use in other conditions, particularly addiction and neurodegenerative diseases, was also discussed, alongside pharmacological prospects and issues surrounding access to these treatments.
By fostering constructive dialogue between researchers and clinicians, the meeting highlighted the importance of connections between basic research, translational research and clinical practice in understanding how these molecules work, optimising their therapeutic applications and assessing their implications for patients and society.
This edition was organised by Ralf Jockers, Catherine Postic, Étienne Larger, Yannick Allanore and Claire Desnos. Institut Cochin thanks the speakers, organisers and all participants for their valuable contributions to the discussions.