The cytoskeleton is a structure that confers to cells their particular shape and mechanical properties. As immune cells are especially motile, they constantly modify their shapes to adapt to their environment for optimal interactions with other cell types. Thus, their cytoskeleton is constantly regulated in time and space thanks to mechanical and chemical inputs that the cells receive from their environment. These signals are then transduced intracellularly by signaling events, often involving RHO GTPases, which in turn alter the polymerization state and activities of cytoskeletal proteins in both innate and adaptive immunity. Our team studies the links between cell mechanics, cytoskeleton and immune responses in pathophysiological settings ranging from single cells to tissues.