Diana Passaro's work focuses on the mechanisms that structure and disrupt the bone marrow niche during acute leukemia. Her team studies how vascular and stromal networks interact with malignant cells and participate in disease progression as well as therapeutic resistance.

Trained at the Institut Curie then at the Francis Crick Institute, she developed an integrative approach combining intravital imaging, transcriptomic analyzes and humanized models. Her research has notably highlighted abnormal vascular properties linking niche structure, cellular heterogeneity and resistance to treatments.

Supported by major competitive funding, including an ATIP-AVENIR program and an ERC Starting Grant, it has contributed to the development of space biology and tissue bioengineering protocols allowing the exploration of human bone marrow under controlled conditions.

At the head of the "Leukemia and niche dynamics" team at the Institut Cochin, Diana Passaro now coordinates projects aimed at deciphering the micro-environmental determinants of leukemic progression, from cellular behavior to tissue architecture, in order to identify new therapeutic targets.