With over 38 million people infected worldwide, HIV remains a major public health issue. Antiviral therapies are effective in limiting virus replication, but its persistence in viral reservoirs hinders the hope of curing patients. The objective of the project developed by the postdoctoral researcher is to deepen knowledge of the molecular mechanisms which contribute to the regulation of the viral and cellular transcriptomes during viral replication and latency. The research program will be based on techniques in cell biology (cell culture, isolation of T lymphocytes from blood samples), virology (viral production and infections), molecular biology (RT-qPCR, Western blot, immunopurification of complexes...), flow cytometry, imaging (immunofluorescence), as well as sequencing analyses (short and long reads).