Symposium Institut Cochin 2024 "Muscle, Exercise and Health"

Understanding and promoting the benefits of physical activity is one of the major public health challenges of our time.
On November 14 and 15, 2024, a symposium on "Muscle, Exercise and Health" will be held at Institut Cochin in Paris. This event will bring together physicians and researchers specializing in the study of muscle and physical activity and the consequences of this activity on aging, neuromuscular diseases, cardiovascular pathologies, cancer and diabetes. Speakers will present their latest findings on the benefits of physical activity in the treatment or prevention of these pathologies. In the context of the Paris 2024 Olympic Games, this symposium will provide an ideal platform to discuss the links between muscular exercise, health and the challenges facing society today.

Research

Programme

Thursday, November 14th

13:00-13:15    Introduction. Florence Niedergang (director of Institut Cochin, Paris, France)

Session 1 - Inter-cellular and inter-organ communications in physiopathology
Chaired by Catherine Postic, Thierry Launay, Iryna Pirozhkova

13:15-14:00    Keynote: Bente Pedersen (University of Copenhagen, Denmark) - Exercise as medicine: focus on myokines
14:00-14:30    Jennifer Arrondeau (ENMC, UMR 8251, Paris, France) - Effect of physical activity on glucose uptake by cancer tumors: “MUSCULOPET study”
14:30-15:00    Jacob Smith (University of Barcelona, Spain) - Circadian rhythms in muscle-liver crosstalk
15:00-15:30    Benedicte Chazaud (INMG, Lyon, France) - The regenerative niche for skeletal muscle regeneration after exercise-induced muscle injury
Coffee break

Session 2 - From pluripotent stem cells to skeletal muscle adaptation limits
Chaired by Athanassia Sotiropoulos, Glenda Comai, Frédéric Relaix

16:15-17:00    The EMBO Keynote lecture: Olivier Pourquié (Harvard Medical School, USA) - Deconstructing human skeletal muscle development in vitro
17:00-17:30    François Goldwasser (Hôpital Cochin & Institut Cochin, Paris, France)  - Host metabolism and antitumour immunotherapy
17:30-18:00    Angèle Merlet (Université Saint Etienne, France) - Exercise therapy: what effect on physical fitness and skeletal muscle tissue? Example of sickle cell disease and perspectives in other pathologies
18:00-18:30    Christophe Handschin (Biozentrum, University of Basel, Switzerland) - The multicellular mechanistic underpinnings of exercise adaptation in skeletal muscle
18:30-18:45    Athanassia Sotiropoulos (GIS FC3R, Maisons-Alfort, France) - How the 3Rs can improve the quality of science and research practices

18:45-19:10    Meeting with Olympic athletes
19:10-20:45    Cocktail/diner - Cloitre Port-Royal

 

Friday, November, 15th

Session 3 - Muscle activity, neuromuscular diseases and therapy
Chaired by Anne Houdusse, Isabelle Richard, Benoit Viollet

09:00-09:45    Keynote: Helen Blau (Baxter Laboratory for Stem Cell Biology, Stanford University School of Medicine, US) - Forget the exercise, take a pill
09:45-10:15   Serge Braun (AFM-Téléthon, EVRY, France)  - Gene therapy of neuromuscular diseases and potential impact of muscle exercise on therapeutic efficacy
10:15-10:45    Olivier Biondi (Université Evry Paris Saclay, France) - Precision exercise in neuromuscular disorders: disease-specific adaptations on mouse models

Coffee break

Session 4 - Muscle activity, neuromuscular diseases, and aging
Chaired by Delphine Duprez, Pascal Maire, Sabrina Pichon

11:15-11:45    Patricia Thoreux (CIMS, Hôpital Hôtel Dieu – HUPC, Paris, France) - Neuromuscular diseases and physical activity: what to think about in 2024
11:45-12:15    Laurent Schaeffer (INMG, Lyon, France) - Chromatin, DNA repair and muscle aging
12:15-12:45    Jerome Feige (Nestlé Institute of Health Sciences S.A., Lausanne, Switzerland) - Mitochondrial Calcium Import Regulates Performance and Aging of Skeletal Muscle
12:45-13:15    Florian Britto (Institut Cochin, Paris, France) - Influence of myofibers typology and metabolism on muscle hypertrophy

Lunch - Cloitre Port-Royal

Session 5 - Myofiber diversity, metabolism and physiopathology
Chaired by Capucine Trollet, Helge Amthor, Frédéric Bouillaud

14:45-15:30    Keynote: Marco Sandri (VIMM, University of Padua, Italy) - Novel insights linking mitochondria, bioenergetics, DNA damage and inflammation with sedentary life
15:30-16:00    Julien Ochala (University of Copenhagen, Copenhagen, Denmark) - Linking myosin to muscle metabolism
16:00-16:30    Kristian Gundersen (Institutt for Biovitenskap, Universitetet i Oslo, Norway) - What determines muscle fiber size?
16 :30-17:00   Jean-François Toussaint (IRMES,URP 7329, INSEP, Paris, France) - Olympism & paralympism: research, limits & development

17:30-18:30    Irène Margaritis (ANSES, France) - General public lecture in French - Nutrition du sportif : un enjeu de performance et de santé

Steering committee

  • Pascal Maire, Inserm researcher
  • Benoit Viollet, Inserm researcher
  • Florian Britto, MCU Université Paris Cité
  • Dominique Zeliszewski, CNRS researcher

Registrations are open until October 31, 2024

Registration fees (tax included):

  • Non academics: 160,00 €
  • Academic labs other than Institut Cochin: 100,00 €
  • Academics Institut Cochin (except students): 50,00 €
  • Students in labs other than Institut Cochin: 40,00 €
  • Institut Cochin students, organizers: free
Register here

Practical Information

Location

  • The symposium will take place in the amphitheater Luton, UFR de Médecine site Cochin, 24 rue du Fg St Jacques, 75014 Paris.
  • The locations of coffee breaks and meals will be indicated soon.

Access

  • Bus 38 - 83 - 91 : stop Observatoire-Port Royal - www.ratp.fr
  • Subway lines 4 - 6 : stop Denfert-Rochereau or Saint-Jacques - www.ratp.fr
  • RER B : stop Denfert-Rochereau or Port-Royal - www.ratp.fr
  • Vélib : Stations n°14112 (24 rue Méchain), 14113 (36 rue de la Santé), 14111 (18 rue Cassini), 14004 (111 bd de Port-Royal) : further information: www.velib-metropole.fr
  • Train: www.sncf.com/fr/
  • Plane: Airports Roissy-Charles de Gaulle, or Orly : www.aeroportsdeparis.fr

Hotels within 20 minutes from the symposium by public transportation

Supports and funding