Understanding heterogeneity of dendritic cells and consequences for T cell activation

Diana Dudziak (Immunology Department chair, Jena University, Germany)

24 April 2025

Seminar

Pratical info

12:00 - 13:00

Conference room Rosalind Franklin

research professional

Reduced mobility access

The main research focus of the Dudziak lab is the understanding of ontogeny, antigen presentation of primary dendritic cell (DC) subpopulations in mice and men and their function in activation of primary T cell immune responses. In her talk, Diana Dudziak will introduce the world of DC subpopulations. She will summarize the function of DC subsets in the induction of T cell responses. Thereafter, she will present the latest data of the lab on DCs in human lymphoid and non-lymphoid tissues and the influence of the tissue microenvironment in DC functionality. Diana Dudziak will finish her presentation by showing latest data on DC subset specific inflammasome-mediated immunomodulation of T cell responses.

Diana Dudziak is invited by Anne Hosmalin.

Bibliography

Clec12A, CD301b, and FcγRIIB/III define the heterogeneity of murine DC2s and DC3s.
Amon L, Seichter A, Vurnek D, Heger L, Lächele L, Tochoedo NR, Kaszubowski T, Hatscher L, Baranska A, Tchitashvili G, Nimmerjahn F, Lehmann CHK, Dudziak D.Cell Rep. 2024 Mar 26;43(3):113949. doi: 10.1016/j.celrep.2024.113949. Epub 2024 Mar 14.PMID: 38492222

XCR1 expression distinguishes human conventional dendritic cell type 1 with full effector functions from their immediate precursors.
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Select hyperactivating NLRP3 ligands enhance the T_H1- and T_H17-inducing potential of human type 2 conventional dendritic cells.
Hatscher L, Lehmann CHK, Purbojo A, Onderka C, Liang C, Hartmann A, Cesnjevar R, Bruns H, Gross O, Nimmerjahn F, Ivanović-Burmazović I, Kunz M, Heger L, Dudziak D.Sci Signal. 2021 Apr 27;14(680):eabe1757. doi: 10.1126/scisignal.abe1757.PMID: 33906973

DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.
Lehmann CHK, Baranska A, Heidkamp GF, Heger L, Neubert K, Lühr JJ, Hoffmann A, Reimer KC, Brückner C, Beck S, Seeling M, Kießling M, Soulat D, Krug AB, Ravetch JV, Leusen JHW, Nimmerjahn F, Dudziak D. J Exp Med. 2017 May 1;214(5):1509-1528. doi: 10.1084/jem.20160951. Epub 2017 Apr 7.PMID: 28389502

Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment.
Heidkamp GF, Sander J, Lehmann CHK, Heger L, Eissing N, Baranska A, Lühr JJ, Hoffmann A, Reimer KC, Lux A, Söder S, Hartmann A, Zenk J, Ulas T, McGovern N, Alexiou C, Spriewald B, Mackensen A, Schuler G, Schauf B, Forster A, Repp R, Fasching PA, Purbojo A, Cesnjevar R, Ullrich E, Ginhoux F, Schlitzer A, Nimmerjahn F, Schultze JL, Dudziak D.Sci Immunol. 2016 Dec 16;1(6):eaai7677. doi: 10.1126/sciimmunol.aai7677. Epub 2016 Dec 16.PMID: 28783692

Differential antigen processing by dendritic cell subsets in vivo.
Dudziak D, Kamphorst AO, Heidkamp GF, Buchholz VR, Trumpfheller C, Yamazaki S, Cheong C, Liu K, Lee HW, Park CG, Steinman RM, Nussenzweig MC.Science. 2007 Jan 5;315(5808):107-11. doi: 10.1126/science.1136080.PMID: 17204652

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