POSTPONED ! The role of cell-intrinsic innate immunity in HIV-1 infection and latency

Christine Goffinet (Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Germany)

26 October 2023

Seminar

Pratical info

12:00 - 13:00

Conference room Rosalind Franklin

research professional

Reduced mobility access

Christine Goffinet is a Prof., leader of the team "Innate Immunity and Viral Evasion" at the Institute of Virology from the Berlin Institute of Health. She is since many years an expert in the HIV-1 field, and now also intensively working on SARS-CoV-2, interested in gaining a better understanding of the interplay between host cells and viruses at the cellular and molecular level.

She is invited by Serge Benichou.

Selected publications

A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913. Kazmierski J, Elsner C, Döhner K, Xu S, Ducroux A, Pott F, Jansen J, Thorball CW, Zeymer O, Zhou X, Fedorov R, Fellay J, Löffler MW, Weber ANR, Sodeik B, Goffinet C. J Immunol. 2022 Jul 18:ji2100685. doi: 10.4049/jimmunol.2100685.

SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression. Niemeyer D, Stenzel S, Veith T, Schroeder S, Friedmann K, Weege F, Trimpert J, Heinze J, Richter A, Jansen J, Emanuel J, Kazmierski J, Pott F, Jeworowski LM, Olmer R, Jaboreck MC, Tenner B, Papies J, Walper F, Schmidt ML, Heinemann N, Möncke-Buchner E, Baumgardt M, Hoffmann K, Widera M, Thao TTN, Balázs A, Schulze J, Mache C, Jones TC, Morkel M, Ciesek S, Hanitsch LG, Mall MA, Hocke AC, Thiel V, Osterrieder K, Wolff T, Martin U, Corman VM, Müller MA, Goffinet C*, Drosten C*. PLoS Biol. 2022 Nov 16;20(11):e3001871. doi: 10.1371/journal.pbio.3001871. eCollection 2022 Nov.

The Tetraspanin CD81 Is a Host Factor for Chikungunya Virus Replication. Lasswitz L, Zapatero-Belinchón FJ, Moeller R, Hülskötter K, Laurent T, Carlson LA, Goffinet C, Simmons G, Baumgärtner W, Gerold G. mBio. 2022 Jun 28;13(3):e0073122. doi: 10.1128/mbio.00731-22.

Absence of cGAS-mediated type I IFN responses in HIV-1-infected T cells. Elsner C, Ponnurangam A, Kazmierski J, Zillinger T, Jansen J, Todt D, Döhner K, Xu S, Ducroux A, Kriedemann N, Malassa A, Larsen PK, Hartmann G, Barchet W, Steinmann E, Kalinke U, Sodeik B, Goffinet C. Proc Natl Acad Sci U S A. 2020 Aug 11;117(32):19475-19486. doi: 10.1073/pnas.2002481117.

Characterization of Endogenous SERINC5 Protein as Anti-HIV-1 Factor. Passos V, Zillinger T, Casartelli N, Wachs AS, Xu S, Malassa A, Steppich K, Schilling H, Franz S, Todt D, Steinmann E, Sutter K, Dittmer U, Bohne J, Schwartz O, Barchet W, Goffinet C. J Virol. 2019 Nov 26;93(24):e01221-19. doi: 10.1128/JVI.01221-19. Print 2019 Dec 15.

The Antiviral Activity of the Cellular Glycoprotein LGALS3BP/90K Is Species Specific. Lodermeyer V, Ssebyatika G, Passos V, Ponnurangam A, Malassa A, Ewald E, Stürzel CM, Kirchhoff F, Rotger M, Falk CS, Telenti A, Krey T, Goffinet C. J Virol. 2018 Jun 29;92(14):e00226-18. doi: 10.1128/JVI.00226-18.

cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites. Xu S, Ducroux A, Ponnurangam A, Vieyres G, Franz S, Müsken M, Zillinger T, Malassa A, Ewald E, Hornung V, Barchet W, Häussler S, Pietschmann T, Goffinet C. Cell Host Microbe. 2016 Oct 12;20(4):443-457. doi: 10.1016/j.chom.2016.09.003.

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