The p53 pathway and metabolism: implications in development, aging and cancer

Laurent Le Cam (Institut de Recherche en Cancérologie de Montpellier)

25 May 2023


Pratical info

12:00 - 13:00
Conference room Rosalind Franklin
research professional
Reduced mobility access

Mutation of the TP53 gene is the most frequent  genetic alteration in human cancers. Tumor supressive function of p53 have been linked to its ability to control cell division, cell death and cellular senescence. However growing evidence indicates that the metabolic functions of p53 play important roles in cancer progression. Our team has been studying the metabolic functions of the p53 pathway for many years and highlited previously unknown functions of several key components of this molecular cascade in pyruvate, amino-acid and nucleotide metabolism. Beyond cancer development, I will illustrate how deregulation of theses metabolic networks impacts on normal physiological responses in the liver and leads to inborn metabolic disorders.

Invited by Béatrice Romagnolo.

Relevant publications

  • Arena et al Mitochondrial MDM2 regulates respiratory complex I activity independently of p53. Mol Cell 2018
  • Cissé et al. targeting MDM2-dependent serine metabolism as a new therapeutic strategy for liposarcoma. Sci Trans Med 2020
  • Lacroix et al. The multifunctional protein E4F1 links p53 to lipid metabolism in adipocytes. Nat Com 2021
  • Di Michele et al. E4F1 coordinates pyruvate mertabolism and the activity of the Eloingator Complex to ensure protein translation fidelity. Bio Rxiv.