Olivier Lichtarge - A New Path to the Genetic Basis of Complex Disease

Olivier Lichtarge

03 October 2022

Séminaire
Photo de Olivier Lichtarge

Infos pratiques

14:00 -
Institut Cochin - Salle Méchain 1
Professionnel de recherche
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Cullen Foundation Chair and Director of the Computational and Integrative Biomedical Research Center, Professor of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA

Abstract

The genotype-phenotype relationship defines evolution in the long run and human health day to day. Because it is rooted in randomness and cryptic selection forces exerted over individuals but mirrored in DNA, this relationship seems intractably complex. Surprisingly, when we frame it formally in fitness landscapes, we find that genes and their mutations obey quantitative rules from statistical physics with characteristic differences in health and disease. In practice, these rules consistently point to genes relevant to population risk of complex diseases, as examples in cancer, autism, Alzheimer’s and diabetes will show.

Some publications

Invited by Ralf Jockers.