Mitochondria are double membrane-bound organelles that perform biosynthetic and signaling roles to control the life and death of the cell.  Mitochondria are paramount to the metabolism and survival of cardiomyocytes, which have the most densely packed inner mitochondrial membrane of all cells.  Cardiomyocytes are exquisitely sensitive to perturbations of mitochondrial structure, which can lead trigger downstream maladaptive and compensatory responses.  In my talk, I will share our latest, unpublished findings using mouse models we have developed that have revealed the importance of inner mitochondrial membrane integrity in restraining cardiac inflammation and the emerging effects that biological sex can have on these phenomena.

Timothy Wai is invited by Molly Ingersoll and Catherine Postic.