IFN-induced activation of dendritic cells and monocytes modulates immune response to yellow fever vaccination

Anne Krug (Institute for Immunology, LMU, Munich, Germany)

28 November 2024

Seminar

Pratical info

12:00 - 13:00

Conference room Rosalind Franklin

research professional

Reduced mobility access

Pr Anne Krug studies the development and plasticity of dendritic cells and monocytes/macrophages, the recognition of viral nucleic acids by dendritic cells, and the regulation of innate and cellular immune responses to viral infection and vaccination. This seminar will focus on her recent work with a consortium on Yellow Fever vaccination

Anne Krug is invited by Anne Hosmalin.

· CCL17 Promotes Colitis-Associated Tumorigenesis Dependent on the Microbiota. Metzger R, Winter L, Bouznad N, Garzetti D, von Armansperg B, Rokavec M, Lutz K, Schäfer Y, Krebs S, Winheim E, Friedrich V, Matzek D, Öllinger R, Rad R, Stecher B, Hermeking H, Brocker T, Krug AB.J Immunol. 2022 Dec 1;209(11):2227-2238. doi: 10.4049/jimmunol.2100867.PMID: 36426975

· Distinct and dynamic activation profiles of circulating dendritic cells and monocytes in mild COVID-19 and after yellow fever vaccination. Winheim E, Eser T, Deák F, Ahmed MIM, Baranov O, Rinke L, Eisenächer K, Santos-Peral A, Karimzadeh H, Pritsch M, Scherer C, Muenchhoff M, Hellmuth JC, von Bergwelt-Baildon M, Olbrich L, Hoelscher M, Wieser A, Kroidl I, Rothenfusser S, Geldmacher C, Krug AB.Eur J Immunol. 2023 Mar;53(3):e2250090. doi: 10.1002/eji.202250090. Epub 2022 Dec 9.PMID: 36404054

· Ly6D+Siglec-H+ precursors contribute to conventional dendritic cells via a Zbtb46+Ly6D+ intermediary stage. Lutz K, Musumeci A, Sie C, Dursun E, Winheim E, Bagnoli J, Ziegenhain C, Rausch L, Bergen V, Luecken MD, Oostendorp RAJ, Schraml BU, Theis FJ, Enard W, Korn T, Krug AB. Nat Commun. 2022 Jun 16;13(1):3456. doi: 10.1038/s41467-022-31054-4.PMID: 35705536

· Impaired function and delayed regeneration of dendritic cells in COVID-19. Winheim E, Rinke L, Lutz K, Reischer A, Leutbecher A, Wolfram L, Rausch L, Kranich J, Wratil PR, Huber JE, Baumjohann D, Rothenfusser S, Schubert B, Hilgendorff A, Hellmuth JC, Scherer C, Muenchhoff M, von Bergwelt-Baildon M, Stark K, Straub T, Brocker T, Keppler OT, Subklewe M, Krug AB. PLoS Pathog. 2021 Oct 6;17(10):e1009742. doi: 10.1371/journal.ppat.1009742. eCollection 2021 Oct.PMID: 34614036

· TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Krug A, French AR, Barchet W, Fischer JA, Dzionek A, Pingel JT, Orihuela MM, Akira S, Yokoyama WM, Colonna M.Immunity. 2004 Jul;21(1):107-19. doi: 10.1016/j.immuni.2004.06.007.PMID: 15345224

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