Air Pollution impact on the Resolution of Inflammation in Mucoviscidosis (cystic fibrosis) airway disease

Maëlys BORN-BONY (Institut Mondor de Recherche Biomédicale, Créteil)

04 June 2026

Seminar

Pratical info

12:00 - 13:00

Conference room Rosalind Franklin

research professional

Reduced mobility access

Cystic fibrosis is a genetic disease characterized by a dehydration of airway mucus leading to increased viscosity, significant inflammation, lung infections and tissue damage. Because progression of the disease cannot be solely explained by genetic factors, some studies are now interested in the intrinsic and extrinsic factors that exacerbate CF symptoms. Among those factors, reduced levels of specialized proresolving lipid mediators (SPM) in CF airway and exposure to air pollution have been reported. In addition, some pollutants have been shown to impact SPM biosynthesis. However, the possible role of air pollution on SPM metabolism dysregulation in CF and the role of SPM in protecting CF airways from air pollution induced damages have not been explored.
In our project, we use Scnn1b transgenic mice as a model for CF airway disease. In collaboration with the LISA (Interuniversity Laboratory of Atmospheric Systems / Laboratoire Interuniversitaire des Systèmes Atmosphériques), we study how exposure to a polluted atmosphere can impact the SPM and, more generally, the resolution of inflammation in the airway.

Paris postdoc seminar series

Publications

Blayac, M. et al. The Impact of Air Pollution on the Course of Cystic Fibrosis: A Review. Front. Physiol. 13, 908230 (2022).
Blayac, M. et al. Acute exposure to realistic simulated urban atmospheres exacerbates pulmonary phenotype in cystic fibrosis-like mice. J. Hazard. Mater. 465, 133340 (2024).
Coll, P. et al. POLLURISK: an innovative experimental platform to investigate health impacts of air quality. in WITT Ecology and Environment vol. 230 557–565 (WIT Press, Naples, Italy, 2018).
Shum, M. et al. CF Patients’ Airway Epithelium and Sex Contribute to Biosynthesis Defects of Pro-Resolving Lipids. Front. Immunol. 13, (2022).
Briottet, M., Shum, M. & Urbach, V. The Role of Specialized Pro-Resolving Mediators in Cystic Fibrosis Airways Disease. Front. Pharmacol.
Briottet, M. et al. Specialized proresolving mediator resolvin E1 corrects the altered cystic fibrosis nasal epithelium cilia beating dynamics. Proc. Natl. Acad. Sci. 121, e2313089121 (2024).
Mall, M., Grubb, B. R., Harkema, J. R., O’Neal, W. K. & Boucher, R. C. Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice. Nat Med 10, 487–93 (2004).

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