Faced with the increase in antibiotic resistance, the use of bacteriophage viruses which specifically infect bacteria appears to be a promising therapeutic alternative. However, bacteria also have the ability to become resistant to bacteriophages. Indeed, during their evolution, bacteria have developed an arsenal of defense systems to protect themselves against bacteriophages. I am mainly interested in the bacterium Pseudomonas aeruginosa, an opportunistic pathogen frequently involved in nosocomial infections and multi-resistant to antibiotics. My research aims to better understand how “anti-bacteriophage” resistance evolves and spreads within bacterial communities and, conversely, how bacteriophages can circumvent this resistance.
Cell differentiation progresses via a continuous lineage restriction process where cell potential is reduced as the embryo develops. Uniquely among vertebrates, a stem cell-like population arising in the most rostral part of the embryo – called cranial neural crest cells (CNCC) – challenges this paradigm. CNCC re-express pluripotency programs to reverse cell differentiation and return into a higher potency state, allowing them to expand their differentiation potential
We seek to understand how this mechanism is regulated and how it could be harnessed to enhance craniofacial regeneration potential.