Membres de l'équipe
Projets
Roberto MALLONE
Sylvaine YOU
Perte de l'ignorance immunitaire
Sylvaine YOU
Roberto MALLONE
Perte de la régulation immunitaire
Sylvaine YOU
Roberto MALLONE
Des thérapies innovantes pour restaurer l'auto-immunité "bénigne".
5 principales publications et brevets
PUBLICATIONS
- Carré A, Vecchio F, Flodstrom-Tullberg M, You S, Mallone R. Coxsackievirus and type 1 diabetes: diabetogenic mechanisms and implications for prevention. Endocrine Reviews, 2023, 44(4): 737-751. doi.org/10.1210/endrev/bnad007
- Corcos N, Culina S, Deligne C, Lavaud C, You S*, Mallone R*. Oral Fc-Coupled Preproinsulin Achieves Systemic and Thymic Delivery Through the Neonatal Fc Receptor and Partially Delays Autoimmune Diabetes. Frontiers in immunology. 2021, 12, 616215. doi: 10.3389/fimmu.2021.616215.
- Azoury ME, Tarayrah M, Afonso G, Pais A, Colli ML, Maillard C, Lavaud C, Alexandre-Heymann L, Gonzalez-Duque S, Verdier Y, Vinh J, Pinto S, Buus S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Eizirik DL, You S, Mallone R. Peptides Derived From Insulin Granule Proteins Are Targeted by CD8 + T Cells Across MHC Class I Restrictions in Humans and NOD Mice. Diabetes. 2020, 69:2678-2690. doi: 10.2337/db20-0013.
- Gonzalez-Duque S, Azoury ME, Colli ML, Afonso G, Turatsinze JV, Nigi L, Lalanne AI, Sebastiani, G, Carré A, Pinto S, Culina S, Corcos N, Bugliani M, Marchetti P, Armanet M, Diedisheim M, Kyewski B, Steinmetz LM, Buus S, You S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Dotta F, Scharfmann, R., Eizirik, DL, Verdier Y, Vinh J, Mallone R. Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors. Cell Metabolism. 2018, 28:946. doi:10.1016/j.cmet.2018.07.007.
- Culina, S., Lalanne, A.I., Afonso, G., Cerosaletti, K., Pinto, S., Sebastiani, G., Kuranda, K., Nigi, L., Eugster, A., Østerbye, T., Maugein, A., McLaren, J.E., Ladell, K., Larger, E., Beressi, J.P., Lissina, A., Appay, V., Davidson, H.W., Buus, S., Price, D.A., Kuhn, M., Bonifacio, E., Battaglia, M., Caillat-Zucman, S., Dotta, F., Scharfmann, R., Kyewski, B., Mallone, R., the ImMaDiab Study Group (2018). Islet-reactive CD8 + T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors. Science immunology 3. 10.1126/sciimmunol.aao4013
BREVETS
- 2022- EB19114 - patent under consideration on “biomarkers of autoimmune T cells for the diagnosis and treatment of type 1 diabetes”, by Inserm-Transfert; inventors R. Mallone, S. You, F. Samassa, M. Giraud.
- 2019 - WO/2019/175380 “Antigenic peptides deriving from Secretogranin V and uses thereof for the diagnosis and treatment of type 1 diabetes” filed by Inserm-Transfert on March 16 2018 (EP18305286); inventors R. Mallone, J. Vinh, D. Eizirik, M. Colli, G. Afonso, S. Gonzalez-Duque, Y. Verdier.
- 2019 - WO/2019/175381 “Antigenic peptides deriving from PCSK2 and uses thereof for the diagnosis and treatment of type 1 diabetes” filed by Inserm-Transfert on March 16 2018 (EP18305287); inventors R. Mallone, J. Vinh, G. Afonso, S. Gonzalez-Duque, Y. Verdier, M.E. Azoury.
- 2019 - WO/2019/175384 “Antigenic peptides deriving from Urocortin 3 and uses thereof for the diagnosis and treatment of type 1 diabetes” filed by Inserm-Transfert on March 16 2018 (EP18305288); inventors R. Mallone, J. Vinh, G. Afonso, S. Gonzalez-Duque, Y. Verdier, M.E. Azoury.
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