The role of anti-PD1 antibodies in tumor-draining lymph nodes

Marion Guerin (Dynamiques des réponses immunes, Institut Pasteur, Paris)

13 février 2025

Séminaire

Infos pratiques

12:00 - 13:00

Salle Rosalind Franklin

Professionnel de recherche

Accès mobilité réduite

Anti-PD-1 therapy targets intratumoral CD8+ T cells to promote clinical responses in cancer patients. Recent evidence has suggested that anti-PD-1 also act in the periphery. In particular, new T cell clonotypes emerge during anti-PD-1 therapy within the tumor microenvironment, suggesting de novo priming in the periphery. However, the underlying mechanism remains incompletely understood. In this presentation, I will show the importance of TDLN during anti-PD-1 therapy and discuss unexpected mechanisms for the peripheral activity of anti-PD-1 antibodies

Paris Post-docs seminar series.

References

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