Microbial viability drives immunometabolic responses of macrophages

Johan Garaude (Mitochondrial Biology and Innate Immunity Team, ImmunoConcEpT, Bordeaux, France)

05 mars 2026

Séminaire

Infos pratiques

12:00 - 13:00

Salle Rosalind Franklin

Professionnel de recherche

Accès mobilité réduite

Johan Garaude is an outstanding cell biologist and immunologist, who is currently leading the Mitochondrial Biology and Innate Immunity team at ImmunoConcEpT.
His team is interested in the cellular metabolism of myeloid cells and how it contributes to innate immunity against microbial pathogens. The laboratory particularly deciphers the mechanism linked to mitochondrial adaptations and nutrient usage in macrophages.
Recently, Johan Garaude recently contributed to show how macrophages recycle ingested bacteria to feed their own metabolism. Using original metabolomic approaches, his team elegantly demonstrated that macrophage use phagocytosed bacteria as a source of nutrients that feed various metabolic pathways including protein synthesis, anti-oxidant responses or central metabolism. Furthermore, his group has shown that microbial viability dictates the fate of ingested cargo by articulating specific metabolic pathways and by re-organizing the architecture of the mitochondrial respiratory chain in phagocytic cells.

Johan Garaude is invited by Fatah Ouaaz.

Selected publications

Juliette Lesbats, Aurélia Brillac, Julie A. Reisz$, Parnika Mukherjee$, Charlène Lhuissier, Mónica Fernández-Monreal, Jean-William Dupuy, Angèle Sequeira, Gaia Tioli, Celia de la Calle Arregui, Benoît Pinson, Daniel Wendisch, Benoît Rousseau, Alejo Efeyan, Leif. E Sander, Angelo D’Alessandro, and Johan Garaude. Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses. Nature, 2025. DOI: 10.1038/s41586-025-08629-4.

News and Views in Nature Immunology by S.N. O’Carroll and L.A.J. O’Neill. DOI: 10.1038/s41590-025-02117-7
Editor’s choice in Science Immunology by Asha Pillai. DOI: 10.1126/sciimmunol.adx7179
Research Highlight in Signal Transduction and Targeted Therapy. DOI: 0.1038/s41392-025-02222-x
Spotlight in Cell Metabolism by Andrea Riviello and Dirk Brenner. DOI: 10.1016/j.cmet.2025.03.018

Garaude J.*,$, Acín-Pérez R.*, Martínez-Cano S.,Enamorado M., Ugolini M., Nistal-Villán E., Hervás-Stubbs S, Pelegrín P., Sander L.E., Enríquez J.A.$, Sancho D.$. Mitochondrial respiratory-chain adaptions in macrophages contribute to antibacterial host defence. Nature Immunology, 2016. doi: 10.1038/ni.3509. (* Equal contributions) ($corresponding authors).

News and Views in Nature Immunology by M.A. Holmbeck and G. Shadel. ni.3534
Research Highlights in Nature Reviews Immunology by E. Kugelberg. nri.2016.83

Torres C., Lhuissier C., and Garaude J., Macrophages use bacteria as a source of nutrients. Med Sci (in press).

Garaude J. Reprogramming of mitochondrial metabolism by innate immunity. Current Opinion in Immunology, 2019. doi: 10.1016/j.coi.2018.09.010 [invited review]

Benmoussa, K., Garaude J.$ and Acín-Pérez, R. $ (2017) How mitochondrial metabolism contributes to macrophage functions. Journal of Molecular Biology, 2018. doi: 10.1016/j.jmb.2018.07.003 ($ Corresponding authors) [invited review]

Sander L.E.$ and Garaude J.$, (2017) The mitochondrial respiratory chain: a metabolic rheostat of antibacterial immunity. Mitochondrion,2017 Oct 17. pii: S1567-7249(17)30224-6 ($ Corresponding authors) [invited review]

Sancho D.$, Enamorado M., Garaude J.$. (2017) Innate immune function of mitochondrial metabolism. Frontiers in Immunology, 2017 May8;8:527. ($ Corresponding authors) [invited review]

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