Neuromesodermal progenitors (NMPs) are axial stem cells that generate much of the posterior body during vertebrate development. Their ability to coordinate growth, differentiation, and morphogenesis is essential for robust embryonic development, yet the mechanisms regulating these processes remain incompletely understood.

Our laboratory combines quantitative imaging, multi-omics approaches, and functional genetics to investigate how developmental, physiological, and environmental cues shape axial stem cell behavior during embryogenesis. In this seminar, I will present recent work uncovering a critical role for folate metabolism during posterior body formation and discuss ongoing efforts to understand how intrinsic and extrinsic signals regulate progenitor cell identity, function, and developmental potential.

Together, our work aims to uncover the molecular and cellular principles that ensure robust posterior axis development and protect against congenital abnormalities.

Invited by Pascal Maire.