Spliceosome Mutations in Myeloid Malignancies

Daniel R. Larson (Laboratory of Receptor Biology and Gene expression, NCI, Bethesda, US)

12 juin 2024


Infos pratiques

12:00 - 13:00
Salle Schapira
Professionnels de la recherche et médecins
Accès mobilité réduite

The differentiation of hematopoietic stem cells into committed lineages in the blood is the result of concerted regulation between transcription, splicing and translation, and a goal of the laboratory is to understand the dynamic interplay between these processes in single cells. Overall, gene regulation in this tissue is exceptionally dependent on post-transcriptional mechanisms, as evidenced in myelodysplasia with mutations in RNA splicing factors. The team has discovered a non-canonical role for the splicing factor U2AF1 in mitochondria homeostasis and reported substantial changes in mitochondrial function and metabolism of MDS cells.

Daniel Larson is invited by Michaela Fontenay.