Mechanics of blastocyst morphogenesis

Jean-Léon Maitre

06 janvier 2022

Photo de Jean-Léon Maitre

Infos pratiques

12h00 -
Professionnel de recherche

Unité "Genetics and developmental biology", Institut Curie, Paris

Invité par Catherine Patrat - Pour obtenir le lien d'accès Zoom, envoyez un mail à webinaire.u1016


During pre-implantation development, the mammalian embryo forms the blastocyst. The architecture of the blastocyst is essential to the specification of the first mammalian lineages and to the implantation of the embryo. Consisting of an epithelium enveloping a fluid-filled lumen and the inner cell mass, the blastocyst is sculpted by a succession of morphogenetic events. These deformations result from the changes in the forces and mechanical properties of the tissue composing the embryo. Combining microscopy, image analysis, biophysical tools and genetics, we study the mechanical and cellular changes leading to the formation of the blastocyst. In particular, we uncover the distinct mechanical strategies adopted by human and mouse embryos to become compacted and how spindle instabilities can trigger cell fragmentation.