11:45     Welcome lunch

13:15     Introduction: Florence Niedergang (Institut Cochin), Pierre-Olivier Couraud (Institut Cochin), Jérôme Bertherat (Institut Cochin and Hôpital Cochin), Yvan de Launoit (CNRS), Gilles Bloch (Inserm), Christine Clérici (Université Paris Cité)

Miltenyi Session 1 – Cancer

Chairpersons: Béatrice Romagnolo and Emmanuel Donnadieu (Institut Cochin)

13:45     Keynote: Isabelle Cremer (Centre de Recherche des Cordeliers, Paris, FR) - The heterogeneity of the lung tumor microenvironment: causal nexus for cancer progression

14:15     Sandrine Etienne-Manneville (Institut Pasteur, Paris, FR) - Intermediate filaments in glioblastoma cell invasion

14:30     Diana Passaro (Institut Cochin, Paris, FR) - The vascular microenvironment in acute leukemia

14:45     Clara Nahmias (Gustave Roussy, Villejuif, FR)- Microtubule-regulating proteins as predictive biomarkers in breast and ovarian cancers

15:00     Michaela Fontenay (Institut Cochin, Paris, FR) - Splicing factors and DNA replication in myeloid hemopathies

15:15     Stefan Eulitz (Customer Liaison Manager, Miltenyi Biotec) - Deep phenotyping with the MACSima Imaging platform, the easy way in spatial Biology                                  

15:30     Coffee break

Miltenyi Session 2 - Immunology

Chairpersons: Anne Hosmalin and Bruno Lucas (Institut Cochin)

16:00      Keynote: Yasmine Belkaid (NIH, NIAID, Bethesda, US)  - Multikingdom control of tissue physiology and repair

16:30     Marc Dalod (Centre d’Immunologie de Marseille-Luminy, Marseille, FR) - Deciphering the molecular regulation of human cDC1 and pDC development and functions

16:45     Julie Helft (Institut Cochin, Paris, FR) - Macrophages and cancer immunity

17:00     Leïla Perié (Institut Curie, Paris, FR) - DRAG barcoding enters the genealomics toolbox

17:15     Agnès Lehuen (Institut Cochin, Paris, FR) - MAIT cells: from metabolic diseases to viral infection

Metabolism and Endocrinology

Chairpersons: Hélène Gilgenkrantz (Inflammation Research Center, Paris) and Stefano Marullo (Institut Cochin)

09:00     Keynote: Michel Bouvier (IRIC, Univ. Montréal, CA) - Functional selectivity and spatiotemporal propagation of GPCR signaling ; opportunities for drug discovery

09:30     Bertrand Cariou (Institut du Thorax, Nantes, FR) - From COCHIN to CHOPIN: Identification of new targets for the treatment of hypercholesterolemia

09:45     Benoit Chassaing (Institut Cochin, Paris, FR) - Host/microbiota interaction at the mucosal surface – importance of the sterile zone!

10:00     Rémi Mounier (Institut NeuroMyoGene, Lyon, FR) - Macrophagic AMPKa1 orchestrates the regenerative inflammation induced by glucocorticoids

10:15     Roberto Mallone (Institut Cochin, Paris, FR) - From benign islet autoimmunity to type 1 diabetes: lessons from the T-cell/beta-cell cross-talk

10:30     Coffee break

Microbiology

Chairpersons: Clarisse Berlioz and Claire Poyart (Institut Cochin)

11:00     Keynote: Philippe Sansonetti (Institut Pasteur, Paris, Shanghai, FR) - Cellular microbiology of the intestinal crypt ecosystem: deciphering microbes-stem cell interaction in health and disease

11:30     Nadine Laguette (Institut de Génétique Humaine, Montpellier, FR) - Fine-tuning of metabolic and inflammatory homeostasis by the STING adaptor protein

11:45     Molly Ingersoll (Institut Cochin, Paris, FR) - Biological sex and host-bacterial interactions in the bladder

12:00     Miriam Lichtner (Sapienza University of Rome, Latina, IT) - Modulation of immune activation/inflammation in COVID-19 pneumonia: from bed to bench side

12:15     Morgane Bomsel (Institut Cochin, Paris, FR) - Sexual transmission of HIV: from mucosal infection and persistence to mucosal protection

12:30     Lunch

Plasticity and Reproduction

Chairpersons: Julie Chaumeil and Pascal Maire (Institut Cochin)

14:30     Keynote: Claudia Mitchell (Director of the Board - Adocia and Coave Therapeutics) - Plasticity: a universal concept from cells to careers

15:00     Patrick Revy (Institut Imagine, Paris, FR) - Somatic genetic rescue in Shwachman-Diamond syndrome

15:15     Antoine Zalc (Institut Cochin, Paris, FR) - Murine cranial neural crest cells reawaken pluripotency programs

15:30     The EMBO Keynote Lecture: François Spitz (Department of Human Genetics, University of Chicago, US) - The genome in 3D : principles and implications for human health

15:45     Daniel Vaiman (Institut Cochin, Paris, FR) - Impediments and paradoxes of sexual reproduction

Conclusion

16:00 - 16:15     Conclusion by Florence Niedergang