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Cellular factors involved in human immunodeficiency virus-1 (HIV-1) early infection steps: KAP1, p21, NLRP3 and SUGT1

During all the steps of HIV-1 replication in the main target cells (activated CD4 T cells and macrophages) the virus takes advantages of the functions of cellular proteins to accomplish efficiently...
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Advances in the pathophysiology of myeloproliferative neoplasms and in their targeted treatments

Isabelle Plo graduated with a Ph.D in Physiopathology (in 2002 at University of Toulouse, G. Laurent). She did a post-doc in DNA repair (2002-2006 at CEA Fontenay-aux-Roses, B. Lopez) and since 2006...
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Pluripotent stem cells in cell therapy and disease modeling in diabetes

Institute of Translational Stem Cell Research, Helmholtz Diabetes Center, Germany Invité par Raphaël Scharfmann
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Institut d'Astrophysique Spatiale (IAS), Orsay invité par le comité Trans-Sciences
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Mechanics of blastocyst morphogenesis

Unité "Genetics and developmental biology", Institut Curie, Paris Invité par Catherine Patrat - Pour obtenir le lien d'accès Zoom, envoyez un mail à webinaire.u1016

Mechanics and polarity in B cells

Paolo Pierobon (Institut Cochin, Paris)

27 octobre 2022

Séminaire

Infos pratiques

12h00 - 13h00
Salle Rosalind Franklin
Professionnel de recherche
Accès mobilité réduite

B cells are the antibody producing cells of immune system. To mount an efficient immune response, they recognize and internalize the antigen through a specific signaling platform called immune synapse. The formation of such a structure entails force generation and polarization of cellular structures. We use microfluidics and micro-fabricated tools to study the forces occurring at the cell-cell contact and the events leading to a rearrangement of the cell upon antigen recognition. We recently introduced functionalized oil droplets as antigen presenting tool and propose an unexpected role for microtubules in restricting F-actin polymerization to allow the formation and maintenance of a unique immune synapse. New projects at institute Cochin are built on these discoveries and include the interaction of these cells with the lymph node microenvironment and the role of mechanics in their immune function.

Paolo Pierobon just arrived in the team Clotilde Randriamampita, with projects at the interface between biophysics and biology. 

He is invited bu Jérôme Delon.

Selected publications:

  • Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes J Pineau, et al, Elife 11, e78330 2022
  • Phenotyping Polarization Dynamics Of Immune Cells Using A Lipid Droplet-Cell Pairing Microfluidic Platform, L Pinon, et al bioRxiv , 2021.12. 22.473360, 2021
  • Actomyosin-driven force patterning controls endocytosis at the immune synapse
  • A Kumari, J Pineau, et al Nature communications 10 (1), 1-14 24, 2019
  • Polarity protein Par3 controls B-cell receptor dynamics and antigen extraction at the immune synapse, A Reversat, et al Molecular biology of the cell 26 (7), 1273-1285 43 2015
  • Polarized secretion of lysosomes at the B cell synapse couples antigen extraction to processing and presentation MI Yuseff,  et al, Immunity 35 (3), 361-374, 2011

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