Biomedical research institute
     
    You are here: Home / Institute / News / 80 PRIME proposal from CNRS, Florence Niedergang is selected for an interdisciplinary PhD project on Phagocytosis

    80 PRIME proposal from CNRS, Florence Niedergang is selected for an interdisciplinary PhD project on Phagocytosis

    •  

    80 PRIME proposal from CNRS, Florence Niedergang is selected 

    The "PhagoChemiForce" project, led by Florence Niedergang in collaboration with two CNRS INC researchers, is one of the 2020 winners of the CNRS call "80 PRIME" (“Projet de Recherche Inter-instituts Multi-Équipes”). This project at the interface between biology, chemistry and physics, will shed unprecedented light on the complexity of phagocytosis mediated by multiple receptors of pathophysiological importance.

     

    Created in 2019 by the Mission for transversal and interdisciplinary initiatives (MITI) on the occasion of the 80th anniversary of the CNRS, the 80 PRIME call promotes multi-team research projects involving at least 2 Institutes, to support and strengthen the interdisciplinarity at CNRS.

    The project “PhagoChemiForce - Disentangling phagocytosis complexity using chemically multiresponsive and deformable particles” will be led by the team of Florence Niedergang, in collaboration with those of Jacques Fattaccioli (Microfluidic Laboratory Institut Pierre Gilles de Gennes, ENS, Sorbonne University) and Jean-Maurice MALLET (Laboratory of Biomolecules, ENS, Sorbonne University). 80 PRIME support also includes funding for a 3-year doctoral contract at the Institut Cochin.

     

    This proposal aims at untangling critical steps of phagocytosis in macrophages taking advantage of a multi-disciplinary approach and unique deformable emulsion droplets coated with novel fluorescent receptor-targeted ligands to detect by FRET receptors binding and clustering, and to monitor directly the forces generated by the phagocyte. 

    The project will focus on receptors for important pathogenic microbes, which have been overlooked so far, mannose receptors, and their cross talk with complement receptors. Important regulators of force generation and phagosome formation will then be identified in primary macrophages using these unique read-outs. 

     

    PhD position offer: https://emploi.cnrs.fr/Offres/Doctorant/UMR8104-FLONIE-001/Default.aspx