Biomedical research institute


    PUBLICATIONS (2014-2018)


    1. Kuranda K, Caillat-Zucman S, You S, Mallone R. In vitro expansion of anti-viral T cells from cord blood by accelerated co-cultured dendritic cells. Mol Ther Methods Clin Dev (2018), 13:112-120 doi: 10.1016/j.omtm.2018.12.010.

    2. Dehghani L, Mikail N, Kramkimel N, Soyer P, Lebtahi R, Mallone R, Larger E. Autoimmune pancreatitis after nivolumab anti-programmed death receptor-1 treatment. Eur J Cancer (2018), 104:243-246 (2018). doi: 10.1016/j.ejca.2018.09.014.

    3. Buitinga M, Callebaut A, Marques Câmara Sodré F, Crèvecoeur I, Blahnik-Fagan G, Yang M.L, Bugliani M, Arribas-Layton D, Marré M, Cook D.P, Waelkens E, Mallone R, Piganelli J.D, Marchetti P, Mamula M, Derua R, James E.A, Mathieu C, Overbergh L. Inflammation-induced citrullinated glucose-regulated protein 78 elicits immune responses in human type 1 diabetes. Diabetes (2018), 67:2337-2348. doi: 10.2337/db18-0295.

    4. Gonzalez-Duque S, Azoury ME, Colli ML, Afonso G, Turatsinze JV, Nigi L, Lalanne AI, Sebastiani G, S. Pinto, Carré A, Pinto S, Culina S, Corcos N, Bugliani M, Marchetti P, Armanet M, Diedisheim M, Kyewski B, Steinmetz LM, Buus S, You S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Dotta F, Scharfmann R, Eizirik DL, Verdier Y, Vinh J, R. Mallone. Conventional and neo-antigenic peptides presented by β cells are targeted by circulating naïve CD8+ T cells in type 1 diabetic and healthy donors. Cell Metab (2018), 28:946-960.e6; doi: 10.1016/j.cmet.2018.07.007.

    5: Culina S, Lalanne A.I, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, Kuranda K, Nigi L, Eugster A, Østerbye T, Maugein A, McLaren J.E, Ladell K, Larger E, Beressi J.P, Lissina A, Appay V, Davidson H.W, Buus S, Price D.A, Kuhn M, Bonifacio E, Battaglia M, Caillat-Zucman S, Dotta F, Scharfmann R, Kyewski B, Mallone R, the ImMaDiab Study Group. Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetes from healthy donors. Sci Immunol (2018), 3:eaao4013; doi: 10.1126/sciimmunol.aao4013.

    6. Bonnet-Serrano F, Diedisheim M, Mallone R, Larger E. Decreased alpha-cell mass and early structural alterations of the exocrine pancreas in patients with type 1 diabetes: an analysis based on the nPOD repository. PLoS One (2018), 13:e0191528. doi: 10.1371/journal.pone.0191528.

    7. James E.A, Abreu J.R.F, McGinty J.W, Odegard J.M, Fillié Y.E, C.N. Hocter C.N, S. Culina S, K. Ladell K, Price D.A, Alkanani A, Rihanek M, Fitzgerald-Miller L, A. Skowera A, C. Speake C, Greenbaum C, Gottlieb P, Davidson H, Wong F.S, Roep B, Mallone R, the Immunology of Diabetes Society T Cell Workshop Committee. Combinatorial detection of autoreactive CD8+ T cells with HLA-A2 multimers: a multicenter study by the Immunology of Diabetes Society T Cell Workshop. Diabetologia (2018), 61:658-670. doi: 10.1007/s00125-017-4508-8.

    8: Besançon A, Goncalves T, Valette F, Mary C, Vanhove B, Chatenoud L, You S. A selective CD28 antagonist and rapamycin synergise to protect against spontaneous autoimmune diabetes in NOD mice. Diabetologia (2018), 61(8):1811-1816. doi: 10.1007/s00125-018-4638-7.

    9: Besançon A, Demir Z, Goncalves T, Valette F, Panafieu E, Chatenoud L, You S. Differential impact of T-bet and IFNγ on pancreatic islet allograft rejection. Transplantation (2018), 102(9):1496-1504. doi: 10.1097/TP.0000000000002261.

    10: You S, Chatenoud L. Revisiting the phenotypic and genetic profiling of anergic T cells mediating long-term transplant tolerance. Curr Opin Organ Transplant (2018), 23(1):83-89. doi: 10.1097/MOT.0000000000000494.

    11: Besançon A, Goncalves T, Valette F, Dahllöf MS, Mandrup-Poulsen T, Chatenoud L, You S. Oral histone deacetylase inhibitor synergises with T cell targeted immunotherapy to preserve beta cell metabolic function and induce stable remission of new-onset autoimmune diabetes in NOD mice. Diabetologia (2018), 61(2):389-398. doi: 10.1007/s00125-017-4459-0.

    12: Besançon A, Baas M, Goncalves T, Valette F, Waldmann H, Chatenoud L, You S. The Induction and Maintenance of Transplant Tolerance Engages Both Regulatory and Anergic CD4(+) T cells. Front Immunol (2017), 8:218. doi: 10.3389/fimmu.2017.00218.

    13. Masat E, Laforêt P, De Antonio M, Corre G, Perniconi B, Taouagh N, Mariampillai K, Amelin D, Mauhin W, Hogrel J.Y, Caillaud C, Ronzitti G, Puzzo F, Kuranda K, Colella P, Mallone R, Benveniste O, Mingozzi F. Long-term exposure to Myozyme results in a decrease of anti-drug antibodies in late-onset Pompe disease patients. Sci Rep (2016), 6:36182. doi: 10.1038/srep36182.

    14. Pérol L, Lindner J.M, Caudana P, Nunez N, Baeyens A, Valle A, C. Sedlik C, Loirat D, Boyer O, Créange A, Cohen J.L, Rogner U.C, Yamanouchi J, Marchant M, Leber X.C, Scharenberg M, Santamaria P, Gagnerault M.C, Mallone R, Battaglia M, Hartemann A, Traggiai E, Piaggio E. Loss of immune tolerance to IL-2 in type 1 diabetes. Nat Commun (2016), 7:13027. doi: 10.1038/ncomms13027.

    15. Diedisheim M, Mallone R, Boitard C, Larger E. Beta-cell mass in non-diabetic autoantibody-positive subjects: an analysis based on the Network for Pancreatic Organ Donors database. J Clin Endocrinol Metab (2016), 101:1390-1397. doi: 10.1210/jc.2015-3756.

    16. Lissina A, Briceno O, Afonso G, Larsen M, Gostick E, Price D.A, Mallone R, Appay V. Priming of qualitatively superior human effector CD8+ T cells using TLR8 ligand combined with FLT3L. J Immunol (2016), 196:256-263. doi: 10.4049/jimmunol.1501140.

    17: Kuhn C, Besançon A, Lemoine S, You S, Marquet C, Candon S, Chatenoud L. Regulatory mechanisms of immune tolerance in type 1 diabetes and their failures. J Autoimmun (2016), 71:69-77. doi: 10.1016/j.jaut.2016.05.002.

    18: Baas M, Besançon A, Goncalves T, Valette F, Yagita H, Sawitzki B, Volk HD, Waeckel-Enée E, Rocha B, Chatenoud L, You S. TGFβ-dependent expression of PD-1 and PD-L1 controls CD8(+) T cell anergy in transplant tolerance. Elife (2016), 5:e08133. doi: 10.7554/eLife.08133.

    19: You S, Chatenoud L. Autoimmune Diabetes: An Overview of Experimental Models and Novel Therapeutics. Methods Mol Biol (2016), 1371:117-42. doi: 10.1007/978-1-4939-3139-2_8.

    20: Calderon D, Prot M, You S, Marquet C, Bellamy V, Bruneval P, Valette F, de Almeida P, Wu JC, Pucéat M, Menasché P, Chatenoud L. Control of Immune Response to Allogeneic Embryonic Stem Cells by CD3 Antibody-Mediated Operational Tolerance Induction. Am J Transplant (2016), 16(2):454-67. doi: 10.1111/ajt.13477.

    21. Xu X, Gu Y, Bian L, Shi Y, Cai Y, Chen Y, Chen H, Qian L, Wu X, Xu K, Mallone R, Davidson H.W, Yu L, She J, Zhang M, Yang T. Characterization of immune response to novel HLA-A2-restricted epitopes from zinc transporter 8 in type 1 diabetes. Vaccine (2015), 34:854-862. doi: 10.1016/j.vaccine.2015.10.108.

    22. Briceño O, Lissina A, Wanke K, Afonso G, von Braun A, Ragon K, Miquel T, Gostick E, Papagno L, Stiasny K, Price D.A, Mallone R, Sauce D, Karrer U, Appay V. Reduced naïve CD8+ T-cell priming capacity in the elderly and in HIV infected individuals. Aging Cell (2015), 15:14-21 (2015). doi: 10.1111/acel.12384.

    23. Culina S, Gupta N, Boisgard R, Afonso G, Gagnerault M.C, Dimitrov J, Østerbye T, Justesen S, Luce S, Attias M, Kyewski B, Buus S, Wong F.S, Lacroix-Desmazes S, Mallone R. Materno-fetal transfer of preproinsulin through the neonatal Fc receptor protects from autoimmune diabetes. Diabetes (2015) 64:3532-3542. doi: 10.2337/db15-0024.

    24. Rosenzwajg M, Churlaud G, Mallone R, Six A, Derian N, Chaara W, Lorenzon R, Long A, Buckner J, Afonso G, Pham H.P, Hartemann A, Yu A, Pugliese A, Malek T.R, Klatzmann D. Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients. J Autoimmun (2015), 58:48-58. doi: 10.1016/j.jaut.2015.01.001.

    25. Gupta N, Culina S, Meslier Y, Dimitrov J, Arnoult C, Delignat S, Gangadharan B, Lecerf M, Justesen S, Gouilleux-Gruart V, Salomon B.L, Scott D.W, Kaveri S.V, Mallone R, Lacroix-Desmazes S. Regulation of immune responses to antigens and protein therapeutics by transplacental induction of central and peripheral T-cell tolerance. Sci Transl Med (2015), 7:275ra21. doi: 10.1126/scitranslmed.aaa1957.

    26. Mallone R, Culina S. Of bugs and men: antigen-fortified Lactoccoccus lactis for type 1 diabetes immunotherapy. Diabetes (2014), 63: 2603-2605. doi: 10.2337/db14-0587.

    27: Baas MC, Kuhn C, Valette F, Mangez C, Duarte MS, Hill M, Besançon A, Chatenoud L, Cuturi MC, You S. Combining autologous dendritic cell therapy with CD3 antibodies promotes regulatory T cells and permanent islet allograft acceptance. J Immunol (2014), 193(9):4696-703. doi: 10.4049/jimmunol.1401423.