Team leader
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Clotilde Randriamampita DR2 CNRS
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Our team is interested in signaling events triggered in T lymphocytes upon activation or chemokine stimulation and aims at understanding how HIV-1 is able to hijack these cellular pathways to optimize its dissemination and replication in host cells.
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Objectives
The objectives of our team are to study issues related to the dynamics of immune cell signaling and retroviral infection.
We are studying early signaling events triggered in T lymphocytes stimulated with chemokines and want to determine how GTPases of the Rho family are regulated upon T cell activation and stimulation (lien vers JD). We also analyze the role of FoxO1, a major transcription factor which controls T cell migration and activation (lien vers MM)
Macrophages and dendritic cells are HIV-1 targets which participate to viral pathogenesis. Our objective is to characterize cellular and viral mechanisms involved in HIV-1 transfer and intercellular dissemination in target myeloid cells.
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M. Mangeney |
J. Delon |
S. Bénichou |
C. Randriamampita |
Main publications
- Roux A, Bracq L, De Muylder B, Leroy H, Oussous S, Dusanter-Fourt I, Chougui G, Tacine R, Randriamampita C, Desjardins D, Le Grand R, Bouillaud F, Benichou S, Margottin-Goguet F, Cheynier R, Bismuth G & Mangeney M. FOXO1 transcription factor plays a key role in T cell – HIV-1 interaction. PlosPathogens. Sous presse.
- Megrelis, L., El Ghoul, E., Moalli, F., Versapuech, M., Cassim, S., Ruef, N., Stein, J.V., Mangeney, M. and Delon J. (2018) Fam65b phosphorylation relieves tonic RhoA inhibition during T cell migration. Front Immunol. 9:2001
- Bracq, L., Xie, M., Lambelé, M., Vu, L.-T., Matz, J., Schmitt, A., Delon, J., Zhou, P., Randriamampita, C., Bouchet, J., and Benichou, S. (2017). T cell-macrophage fusion triggers multinucleated giant cell formation for HIV-1 spreading. J. Virol., 91, e01237-17.
- Liu, L., Wang, W., Matz, J., Ye, C., Bracq, L., Delon, J., Kimata, J., Chen, Z., Benichou, S.* and Zhou, P.* (2016) Glycosyl Phosphatidylinositol-Anchored Variable Region of Llama Heavy Chain Only Antibody JM4 Efficiently Blocks Both Cell-Free and T Cell-T Cell Transmission of Human Immunodeficiency Virus Type 1. J. Virol., 90, 10642-10659. (*equal contribution)
- Guedj, C., Abraham, N., Jullié, D., Randriamampita, C. (2016) T cell adhesion triggers an early signaling pole distal to the immune synapse. J Cell Sci. 129: 2526-2537
- Froehlich, J., Versapuech, M., Megrelis, L., Largeteau, Q., Meunier, S., Tanchot, C., Bismuth, G., Delon, J., Mangeney, M. (2016). FAM65B controls the proliferation of transformed and primary T cells. Oncotarget. 7: 63215-63225.
Team's news
- Serge Benichou est directeur du Laboratoire International Associé (LIA VirHost) établi entre son groupe de l'Institut Cochin et l'Institut Pasteur de Shanghai.
- Accueil d'étudiants en Thèse chinois dans le cadre du programme du "Chinese Scholarship Council".
- Lauréats du Prix de l'Institut Cochin (Journées des Doctorants) : Lucie Bracq (2016), Laura Megrelis (2014), Chloé Guedj (2013).
- L'équipe participe activement au Programme Apprenti-Chercheur mis en place depuis plusieurs années à l'Institut Cochin en partenariat avec l'Arbre des connaissances
- L'équipe est membre du club cytosquelette parisien et participe activement au groupe Biosensor du GDR Imabio