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    Team: Biology of Phagocytes, Infection and Immunity

    Team leader
     

    CV Aviesan

    Phagocytosis is the mechanism of capture and degradation of pathogens or debris that is performed by professional cells of the immune system. We study the mechanims of capture and degradation by phagocytic cells, their impact on immune responses and their alterations by viral infections, which can lead to the development of bacterial co-infections or uncontrolled inflammation.

     

    Objectives

    Professional phagocytes play a major role in innate and adaptive immune responses. Phagocytosis and degradation of invading microorganisms or debris is crucial for bacterial clearance and resolution of inflammation. Therefore, it is crucial to understand the mechanisms of phagocytosis, especially of cell debris or microorganisms.

    Our first goal is to dissect the mechanisms used by phagocytes, in particular the coordinated activities of signaling pathways, membrane trafficking and cytoskeleton dynamics, and their effect on the outcome of immune responses, including presentation of antigens to B cells. Second, we analyze how viruses, including HIV, respiratory viruses associated with lung inflammation or Zika virus, impair these phagocytic and activation functions.


    Recent publications :

    Lafuente EM*, Niedergang F*, Rosales C*. Editorial: Phagocytosis: Molecular Mechanisms and Physiological Implications. Front Immunol. (2020) 11:586918. (* co-corr authors)

    Bamia A, Marcato V, Boissière M, Mansuroglu Z, Tamietti C, Romani M, Simon D, Tian G, Niedergang F, Panthier JJ, Flamand M, Souès S, Bonnefoy E. The NSs Protein Encoded by the Virulent Strain of Rift Valley Fever Virus Targets the Expression of Abl2 and the Actin Cytoskeleton of the Host, Affecting Cell Mobility, Cell Shape, and Cell-Cell Adhesion. J Virol. (2020) 95:e01768-20.

    Al-Mukh H, Baudoin L, Bouaboud A, Sanchez-Salgado JL, Maraqa N, Khair M, Pagesy P, Bismuth G, Niedergang F, Issad T. Lipopolysaccharide Induces GFAT2 Expression to Promote O-Linke b-N-Acetylglucosaminylation and Attenuate Inflammation in Macrophages. The Journal of Immunology (2020) 205:2499-2510.

    El-Barbry, H., Capitao, M., Barrin, S., Amziani, S., Pierre-Paul, P., Borreill, S., Guilbert, T., Donnadieu, E., Niedergang, F*, and Ouaaz, F*. Extracellular release of antigen by dendritic cell regurgitation promotes B cell activation through NF-κB/cRel. The Journal of Immunology (2020), 205:608-618

    Anna Mularski and Florence Niedergang (2020). Force Measurement of Living Professional Phagocytes of the Immune System. Australian Journal of Chemistry - https://doi.org/10.1071/CH19409

    Lê-Bury G, Deschamps C, Kizilyaprak C, Blanchard W, Daraspe J, Dumas A, Gordon MA, Hinton JCD, Humbel BM, Niedergang F. Increased intracellular survival of Salmonella Typhimurium ST313 in HIV-1-infected primary human macrophages is not associated with Salmonella hijacking the HIV compartment. Biol Cell. 2020 Jan 10. doi: 10.1111/boc.201900055

    Jubrail, J., Africano-Gomez, K., Herit, F., Mularski, A., Bourdoncle, P., Oberg, L, Israelsson, E., Burgel, P-R., Mayer, G., Mootoosamy Cunoosamy, D., Kurian, N., and Niedergang F. Arpin is critical for phagocytosis in macrophages and is targeted by human rhinovirus. EMBO Rep. (2020). e47963. doi: 10.15252/embr.201947963

    Boncompain G, Herit F, Tessier S, […], Brelot A, Niedergang F, Perez F. Differential screening identifies molecules specifically inhibiting CCR5 transport to the cell surface and HIV infection. bioRxiv. Doi.org/10.101364927. Science Advances (2019); 5: eaax0821. doi: 10.1126/sciadv.aax0821

    Niedergang F. Dendritic cells mature to resist lamin degradation and herpes virus release. J. Cell Biol. (2019). 4;218(2):387-388. doi: 10.1083/jcb.201812051.

    Jubrail, J., Africano-Gomez, K., Herit, F., Baturcam, E., Mayer, E., Mootoosamy Cunoosamy, D., Kurian, N., and Niedergang, F. HRV16 impairs macrophages cytokine response to a secondary bacterial trigger. Front. Immunol. (2018) 9:2908

    Lê-Bury G and Niedergang F Defective phagocytic properties of HIV-infected macrophages: how might they be implicated in the development of invasive Salmonella Typhimurium ? Front. Immunol. (2018) 9:531

    Niedergang, F. and Grinstein, S. How to build a phagosome: new concepts for an old process. Curr Op Cell Biol  (2018) 50:57-63

    Team's news

      • Florence Niedergang is invited speaker at the next "Phagocyte" Gordon Research Conference in October 2021
      • Florence Niedergang is invited speaker at the « Cell Dynamics Host pathogen Interface rescheduled from May 2020 in UK, to 2022 in Portugal!
      • ANR programmes PhagoChemiForce and NeuroZika started in 2021
      • The lab will participate to the Declics outreach activity in 2021
      • Laura Jacquelin started her PhD in October 2020 as part of the 80 PRIME CNRS programme, for an interdisciplinary collaborative work on phagocytosis with Jacques Fattaccioli (ENS and IPGG) and Jean-Maurice Mallet (ENS)
      • Manon Depierre started her PhD in September 2020 to study how human rhinoviruses modify the macrophages functions
      • The lab participated to the 2020 “Fête de la Science” event for general public to discuss “How sentinel immune cells are hijacked by microbes”
      • Filipa Campos joined the lab in February 2020 as M2 ERASMUS student and did excellent work despite quarantine
      • Floriane Herit started as PhD student in January 2020 and presented a poster at the 2020 “Sidaction scientific day”