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    Team: Pathogenesis and innovative therapies in chronic fibro-inflammatory diseases

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    Team leaders:

     

    Objectives

    Systemic sclerosis, rheumatoid arthritis and endometriosis are chronic fibro-inflammatory diseases, affecting the connective tissue, the joints and the peritoneal cavity respectively. The pathophysiology of these diseases is incompletely understood but it depends on the interaction of genetic susceptibility and environmental factors. Our team has a long history of dismantling the pathophysiology of these complex diseases. Our strategies are based on the study of genetic bases, polarizations of innate and adaptive immune responses, the role of oxidative stress in the interfaces between these systems, epigenetic modifications involved in the dysfunction of the cells involved (such as fibroblasts) and chronic inflammation. Our ultimate goal is to identify interesting biomarkers and new therapeutic approaches. We have built a large bank of biological samples from patients (DNA, RNA, serum, plasma, tissue and cells), with the aim of developing a research that can be applied for the patients. In addition, we have set up a platform of preclinical mouse models that reproduce different aspects of these pathologies and make it possible to explore in detail any candidate therapeutic molecule. We work closely with the clinical teams from Cochin Hospital so that our research can benefit patients as much as possible.

    Systemic sclerosis

    Rheumatoid arthritis

    Endometriosis

     

    Team’s news

    • Journée JC Dreyfus. ROS in physiology & diseases. Sept 2019– F Batteux, Chaiman
    • Paris Redox World Congress 20-21 June 2019 – F Batteux, Chaiman, C Nicco, Board
    • SEUD meeting 16-18 May 2019 (Montreal) – Pr C Chapron, Board
    • Pr Jérome Avouac did present some data at the last American College of Rheumatology meeting (Chicago October 2018)

     

    Main Publications

     

    • Peyneau M, Kavian N, Chouzenoux S, Nicco C, Jeljeli M, Toullec L, Reboul-Marty J, Chenevier-Gobeaux C, Reis FM, Santulli P, Doridot L, Chapron C, Batteux F. Role of thyroid dysimmunity and thyroid hormones in endometriosis. Proc Natl Acad Sci U S A. 2019 Jun 11
    • Avouac J, Pezet S, Gonzalez V, Baudoin L, Cauvet A, Ruiz B, Boleto G, Brandely ML, Elmerich M, Allanore Y. Estrogens counteract the profibrotic effects of TGF-β and their inhibition exacerbates experimental dermal fibrosis. J Invest Dermatol. 2019 Aug 30. pii: S0022-202X(19)33206-3.
    • Kavian N, Mehlal S, Jeljeli M, Saidu NEB, Nicco C, Cerles O, Chouzenoux S, Cauvet A, Camus C, Ait-Djoudi M, Chéreau C, Kerdine-Römer S, Allanore Y, Batteux F. The Nrf2 Antioxidant Response Element Signaling Pathway Controls Fibrosis and Autoimmunity in Scleroderma. Front Immunol. 2018 Aug 16;9:1896.
    • Leblond A, Pezet S, Trouvin AP, Elhai M, Gonzalez V, Allanore Y, Avouac J. Linking systemic angiogenic markers to synovial vascularization in rheumatoid arthritis. PLoS One. 2018 Sep 6;13(9):e0203607. doi: 10.1371/journal.pone.0203607. eCollection 2018.
    • Avouac J, Guignabert C, Hoffmann-Vold AM, Ruiz B, Dorfmuller P, Pezet S, Amar O, Tu L, Van Wassenhove J, Sadoine J, Launay D, Elhai M, Cauvet A, Subramaniam A, Resnick R, Hachulla E, Molberg Ø, Kahan A, Humbert M, Allanore Y. Role of Stromelysin 2 (Matrix Metalloproteinase 10) as a Novel Mediator of Vascular Remodeling Underlying Pulmonary Hypertension Associated with Systemic Sclerosis. Arthritis Rheumatol. 2017 Nov;69(11):2209-2221
    • Avouac J, Konstantinova I, Guignabert C, Pezet S, Sadoine J, Guilbert T, Cauvet A, Tu L, Luccarini JM, Junien JL, Broqua P, Allanore Y. Pan-PPAR agonist IVA337 is effective in experimental lung fibrosis and pulmonary hypertension. Ann Rheum Dis. 2017
    • Terao C, Kawaguchi T, Dieude P, Varga J, Kuwana M, Hudson M, Kawaguchi Y, Matucci-Cerinic M, Ohmura K, Riemekasten G, Kawasaki A, Airo P, Horita T, Oka A, Hachulla E, Yoshifuji H, Caramaschi P, Hunzelmann N, Baron M, Atsumi T, Hassoun P, Torii T, Takahashi M, Tabara Y, Shimizu M, Tochimoto A, Ayuzawa N, Yanagida H, Furukawa H, Tohma S, Hasegawa M, Fujimoto M, Ishikawa O, Yamamoto T, Goto D, Asano Y, Jinnin M, Endo H, Takahashi H, Takehara K, Sato S, Ihn H, Raychaudhuri S, Liao K, Gregersen P, Tsuchiya N, Riccieri V, Melchers I, Valentini G, Cauvet A, Martinez M, Mimori T, Matsuda F, Allanore Y. Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis. Ann Rheum Dis. 2017
    • Elhai M, Avouac J, Hoffmann-Vold AM, Ruzehaji N, Amiar O, Ruiz B, Brahiti H, Ponsoye M, Fréchet M, Burgevin A, Pezet S, Sadoine J, Guilbert T, Nicco C, Akiba H, Heissmeyer V, Subramaniam A, Resnick R, Molberg Ø, Kahan A, Chiocchia G, Allanore Y. OX40L blockade protects against inflammation-driven fibrosis. Proc Natl Acad Sci U S A. 2016
    • Morin F, Kavian N, Nicco C, Cerles O, Chéreau C, Batteux F. Improvement of Sclerodermatous Graft-Versus-Host Disease in Mice by Niclosamide. J Invest Dermatol. 2016

     

    Contact

    Institut Cochin, Equipe Allanore Batteux
    INSERM U1016, CNRS UMR 8104, Université Paris Descartes
    Bâtiment Gustave Roussy - 4ème étage
    22 rue Méchain
    75014 Paris, France